Introduction to 4-Amino-3-Fluoropyridine

4-Amino-3-fluoropyridine, identified by its CAS number 2247-88-3, stands as a noteworthy chemical compound within the realm of organic chemistry. Often recognized by its synonyms such as 3-fluoropyridin-4-amine, this molecule plays a pivotal role in the synthesis of various pharmaceutical intermediates. With a molecular formula of C5H5FN2 and a molecular weight of 112.10500, it embodies a unique blend of fluorine and nitrogen atoms that enhance its reactivity and utility in drug development.

The compound appears as yellow crystals, boasting a purity level of ≥99.0%, which underscores its quality for industrial applications. Its physical properties, including a density of 1.3±0.1 g/cm3 and a melting point ranging from 74-77°C, make it a stable yet versatile substance under controlled conditions. This article aims to explore its characteristics, applications, and the significance of sourcing it from a reliable 4-Amino-3-fluoropyridine manufacturer in China.

Chemical and Physical Properties

The chemical structure of 4-Amino-3-fluoropyridine is defined by its fluorinated pyridine ring, which contributes to its distinctive physical and chemical properties. It has a boiling point of 217.1±20.0 °C at 760 mmHg, indicating its thermal stability, while its flash point of 85.1±21.8 °C suggests moderate flammability that requires careful handling. The refractive index of 1.554 further reflects its optical characteristics, which can be crucial in analytical chemistry.

These attributes are not merely academic; they directly influence how this compound behaves during synthesis processes. For instance, its density and melting point ensure it remains solid and manageable at room temperature, facilitating storage and transportation. When stored in a tightly closed container in a cool, dry environment, 4-Amino-3-fluoropyridine maintains its integrity, making it a preferred choice for manufacturers seeking a dependable 4-Amino-3-fluoropyridine supplier in China.

Applications in Pharmaceutical Intermediates

The primary application of 4-Amino-3-fluoropyridine lies in its role as a building block for pharmaceutical intermediates. Its fluorinated nature enhances the lipophilicity and metabolic stability of resulting drugs, a critical factor in modern medicinal chemistry. This compound is often utilized in the synthesis of active pharmaceutical ingredients (APIs) that target a range of therapeutic areas, from oncology to neurology.

The presence of both an amino group and a fluorine atom allows for diverse chemical modifications, enabling chemists to tailor molecules with specific pharmacological profiles. This versatility is why industries worldwide seek out high-purity 4-Amino-3-fluoropyridine, often packaged in aluminum foil bags, fluoride bottles, or 25KG fiber drums, depending on the scale of production. As a key ingredient, it underscores the importance of partnering with a trusted pharmaceutical intermediates manufacturer in China to ensure consistent quality and supply.

Manufacturing and Sourcing Insights

China has emerged as a global hub for the production of fine chemicals like 4-Amino-3-fluoropyridine, driven by advanced manufacturing capabilities and cost-effective processes. The production of this compound involves precise control over reaction conditions to achieve its high purity and crystalline form. Techniques such as continuous flow chemistry, which we specialize in, enhance efficiency and scalability, ensuring that large quantities can be produced without compromising quality.

Sourcing from a reputable supplier involves evaluating factors such as packaging options and storage recommendations. For instance, using aluminum foil bags or fiber drums protects the compound from moisture and light, preserving its efficacy. This attention to detail is a hallmark of leading manufacturers who prioritize customer satisfaction and product reliability, making China a preferred destination for those in need of pharmaceutical intermediates.

Why Quality Matters

In the pharmaceutical industry, the quality of intermediates like 4-Amino-3-fluoropyridine can make or break the success of a drug candidate. Impurities or inconsistencies in chemical composition can lead to failed reactions or compromised safety profiles. This is why specifications such as ≥99.0% purity are non-negotiable. Manufacturers must adhere to stringent standards, ensuring that each batch meets the required density, melting point, and other physical benchmarks.

Moreover, the stability of this compound under proper storage conditions—sealed tightly in a cool, dry place—extends its shelf life, reducing waste and costs for end-users. By choosing a supplier with expertise in fine chemicals and pharmaceutical intermediates, companies can mitigate risks and streamline their R&D processes, reinforcing the value of quality sourcing from China.

Our Services and Expertise

Beyond providing insights into compounds like 4-Amino-3-fluoropyridine, our company is dedicated to advancing the field of fine chemicals and pharmaceutical intermediates. Our primary business scope encompasses the research, development, and production of these critical materials. We excel in continuous flow process development and equipment manufacturing, supported by our in-house pilot workshop and extensive external production partnerships.

Our expertise spans a variety of reaction types, including high-temperature, high-pressure, nitration, oxidation, and continuous distillation processes. We offer R&D and manufacturing services for a wide range of products, such as bromides, boric acid, thiophenes, indoles, imidazoles, thiazoles, piperazines, pyrazines, and more, with production capacities ranging from tons to hundreds of tons. Our focus is on products with annual volumes between 100 kg and 100 MT, typically involving up to five synthetic steps.

If you have additional needs or inquiries, please feel free to contact us. We are committed to delivering tailored solutions that meet your specific requirements, leveraging our technical proficiency and production capabilities to support your success in the chemical and pharmaceutical industries.

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