Introduction to 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine

1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine, often abbreviated as TFEDMA, is a specialized fluorinated compound with the molecular formula C4H7F4N and a CAS number of 1550-50-1. Known by various synonyms such as N,N-Dimethyl-1,1,2,2-tetrafluoroethylamine and HCF2CF2NMe2, this chemical stands out in the realm of fluorine-containing reagents due to its unique physical and chemical properties. With a molecular weight of 145.09900, a density of 1.24 g/cm³, and a boiling point of 77ºC, it is a colorless liquid that plays a pivotal role in modern chemical synthesis. Its low flash point of 8ºC and refractive index of 1.451 further define its practical handling and utility in industrial settings.

This compound is increasingly sought after by industries worldwide, particularly as a 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine manufacturer in China scales up production to meet global demand. Its vapor pressure of 0.00106 mmHg at 25°C indicates stability under standard conditions, making it an ideal candidate for various applications.

Synthesis and Chemical Characteristics

The production of 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine typically involves the reaction of tetrafluoroethylene with dimethylamine, a process that yields the compound in high purity, often reaching 96–98% as noted in scientific literature. This reaction is conducted in a controlled environment, often without solvents, highlighting its efficiency and scalability. Unlike reactions with sterically hindered amines, this synthesis proceeds smoothly at low temperatures, avoiding tar formation and ensuring a clean output. The resulting product is highly reactive with water, hydrolyzing to form N,N-dimethylamide of difluoroacetic acid and hydrogen fluoride, a trait that necessitates careful storage and handling.

Its fluorinated structure imparts exceptional stability and reactivity, positioning it as a selective fluorinating agent. This characteristic is particularly valuable when compared to other fluorinating reagents, as it leverages the cost-effective tetrafluoroethylene, making it an economically viable option for large-scale production. For businesses seeking a reliable 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine supplier in China, this compound’s production consistency and quality are critical advantages.

Applications in Industry and Research

The versatility of 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine extends across multiple sectors, notably in pharmaceuticals, agrochemicals, and the development of advanced materials. In pharmaceutical research, it serves as a key reagent for introducing fluorine into organic molecules, a process vital for enhancing the bioactivity and stability of drug candidates. Its ability to convert alcohols into alkyl fluorides with high yields—particularly primary alcohols at elevated temperatures and secondary or tertiary alcohols at lower temperatures—makes it indispensable in synthetic chemistry.

In the agrochemical industry, this compound facilitates the synthesis of fluorinated intermediates used in pesticides and herbicides, contributing to improved efficacy and environmental resistance. Additionally, its role in crafting new materials, such as fluoropolymers and liquid crystals, underscores its importance in cutting-edge technology. The demand for such applications has spurred interest in partnering with a TFEDMA manufacturer in China to ensure a steady supply for innovative projects.

Beyond these primary uses, TFEDMA’s utility as a fluorinated Vilsmeier reagent alternative has been explored, enabling the activation of oximes to produce aryl-cyanides and aryl-amides—compounds critical in drug synthesis and material science. This adaptability highlights its growing relevance in research and development laboratories globally.

Advantages Over Traditional Fluorinating Agents

When compared to traditional fluorinating agents like sulfur tetrafluoride or diethylaminosulfur trifluoride (DAST), 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine offers distinct benefits. Its synthesis relies on tetrafluoroethylene, a less expensive raw material than chlorotrifluoroethylene or hexafluoropropene used in other reagents. Moreover, the water-soluble byproduct of its fluorination reactions simplifies purification processes, a significant advantage in laboratory and industrial settings where product isolation can be challenging. This efficiency, combined with its reasonable stability at ambient temperatures, positions it as a commercially attractive option for fluorochemical synthesis.

For industries prioritizing cost-effectiveness and streamlined workflows, sourcing from a reputable TFEDMA supplier in China can optimize production cycles while maintaining high-quality standards. Its ability to deliver consistent results without the hazards associated with more volatile fluorinating agents further enhances its appeal.

Future Prospects and Industry Trends

The fluorine-containing products industry is witnessing rapid growth, driven by increasing demand for fluorochemicals in pharmaceuticals, electronics, and sustainable materials. As of 2025, China remains a pivotal player in this market, with its robust manufacturing capabilities and focus on fluorination technology development. 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine is poised to benefit from these trends, as its applications align with the global push for innovative, high-performance compounds.

Looking ahead, advancements in continuous flow chemistry and green synthesis methods could further enhance the production of TFEDMA, reducing environmental impact and improving scalability. Companies seeking to stay competitive may find value in collaborating with a 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine manufacturer in China to leverage these emerging technologies and meet evolving market needs.

Our Comprehensive Services

At NINGBO INNO PHARMCHEM CO.,LTD., we pride ourselves on offering more than just premium fluorochemicals like 1,1,2,2-Tetrafluoro-N,N-Dimethylethylamine. Our primary business encompasses the research, development, and production of fine chemicals and pharmaceutical intermediates, including compounds such as bromides, boric acids, thiophenes, indoles, imidazoles, thiazoles, piperazines, and pyrazines. We cater to production volumes ranging from 100 kilograms to 100 metric tons annually, specializing in processes with up to five synthetic steps.

Our expertise extends to continuous flow process development and equipment manufacturing, supported by our in-house pilot workshop and external large-scale production platforms. We excel in reaction types such as high-temperature, high-pressure, nitration, oxidation, and continuous distillation, ensuring tailored solutions for diverse client needs. Whether you require custom synthesis or large-scale manufacturing, feel free to contact us to explore how we can support your next project.

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