Trimethylsilyl Ethanimidoate, also known as (E)-Trimethylsilyl N-(trimethylsilyl)acetimidate, is a versatile organic compound that finds its application in various industrial and laboratory processes. Ningbo Inno Pharmchem Co., Ltd., a leading manufacturer, supplier, and factory of specialty chemicals, produces high-quality Trimethylsilyl Ethanimidoate under the brand name Evonik Degussa Dynasylan BSA.

Properties of Trimethylsilyl Ethanimidoate

Trimethylsilyl Ethanimidoate has a molecular formula of C7H21NOSi3. It is a clear, colorless to light yellow liquid with a molecular weight of 247.5 g/mol. The compound has a density of 0.877 g/mL and a boiling point of 170-172°C. It is highly soluble in organic solvents like methanol, ethanol, and acetone.

Trimethylsilyl Ethanimidoate is a derivative of N,O-Bistrimethylsilylacetamide, also known as N,O-Bis(trimethylsilyl)acetamide. The compound has a similar structure to N,O-Bistrimethylsilylacetamide, except that the amide group is replaced by an imidoate group. The presence of the imidoate group makes Trimethylsilyl Ethanimidoate a more reactive and versatile compound than N,O-Bistrimethylsilylacetamide.

Applications of Trimethylsilyl Ethanimidoate

Trimethylsilyl Ethanimidoate has various applications in the chemical and pharmaceutical industries. The compound is a key reagent in the synthesis of various organic compounds, including amino acids, peptides, and pharmaceuticals. Some of the significant applications of Trimethylsilyl Ethanimidoate are as follows:

1. Protection of Amino Acids and Peptides

Trimethylsilyl Ethanimidoate is a useful reagent in the protection of amino acids and peptides during chemical synthesis. The compound reacts with the amino or carboxylic acid groups of the amino acids or peptides to form stable silyl derivatives, which protect the functional groups from unwanted reactions. The silyl derivatives can be easily removed under mild conditions to regenerate the original amino acids or peptides.

2. Synthesis of Pharmaceuticals

Trimethylsilyl Ethanimidoate is a valuable reagent in the synthesis of various pharmaceuticals. The compound is used in the preparation of intermediate compounds that are critical for the synthesis of drugs like anti-cancer agents, anti-inflammatory drugs, and antibiotics. The use of Trimethylsilyl Ethanimidoate in pharmaceutical synthesis enables the production of high-quality drugs with minimal side effects.

3. Chemical Analysis

Trimethylsilyl Ethanimidoate is used as a derivatization reagent in gas chromatography-mass spectrometry (GC-MS) analysis. The compound reacts with various organic compounds to form volatile silyl derivatives that can be easily analyzed by GC-MS. The use of Trimethylsilyl Ethanimidoate in GC-MS analysis enables the identification and quantification of trace amounts of organic compounds in complex matrices.

4. Other Applications

Trimethylsilyl Ethanimidoate has other applications like the protection of hydroxyl groups in carbohydrates, the synthesis of chiral ligands, and the preparation of polymers and coatings.

Conclusion

Trimethylsilyl Ethanimidoate is a versatile and valuable organic compound with various applications in the chemical and pharmaceutical industries. Ningbo Inno Pharmchem Co., Ltd. is a leading manufacturer, supplier, and factory of high-quality Trimethylsilyl Ethanimidoate under the brand name Evonik Degussa Dynasylan BSA. The compound has excellent properties like high solubility, stability, and reactivity, which make it a popular reagent in various industrial and laboratory processes. The use of Trimethylsilyl Ethanimidoate enables the production of high-quality organic compounds, pharmaceuticals, and chemical analysis results.

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