T-Butyldimethylchlorosilane: Properties, Applications, and Manufacturing by INNO Specialty Chemicals
T-Butyldimethylchlorosilane: Properties, Applications, and Manufacturing by INNO Specialty Chemicals
T-Butyldimethylchlorosilane, also known as TBMS or tert-butyl(chloro)dimethylsilane, is an organosilicon compound that is widely used in the chemical industry. As a versatile reagent, it has various applications in the synthesis of pharmaceuticals, agrochemicals, polymers, and other specialty chemicals. This article will discuss the properties, applications, and manufacturing of TBMS, with a focus on INNO Specialty Chemicals as a leading producer and supplier of this product in China.
Properties of T-Butyldimethylchlorosilane
TBMS is a colorless to pale yellow liquid with a pungent odor. Its chemical formula is C6H15ClSi, and its molecular weight is 150.72 g/mol. The compound has a boiling point of 114-116°C, a melting point of -53°C, and a density of 0.84 g/mL at 25°C. It is soluble in organic solvents such as benzene, toluene, and chloroform, but reacts violently with water, alcohols, and amines. Therefore, TBMS should be handled with care and stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible materials.
TBMS is a versatile reagent that can undergo various chemical reactions, such as nucleophilic substitution, condensation, and hydrosilylation. It can be used as a source of tert-butyl and methyl groups in organic synthesis, as well as a protecting group for alcohols, amines, and carboxylic acids. In addition, TBMS can be used as a crosslinking agent, a silane coupling agent, and a surface modifier in the production of rubber, plastics, coatings, and adhesives.
Applications of T-Butyldimethylchlorosilane
TBMS has numerous applications in the chemical industry, especially in the synthesis of fine chemicals and advanced materials. Some of the key applications of TBMS are as follows:
1. Pharmaceutical intermediates: TBMS is used as a key intermediate for the synthesis of various pharmaceuticals, such as antiviral drugs, anticancer agents, and anti-inflammatory drugs. For example, TBMS can react with nucleoside derivatives to form tert-butyl esters, which can be further transformed into nucleotide analogs that inhibit viral replication.
2. Agrochemicals: TBMS is used as a building block for the synthesis of herbicides, insecticides, and fungicides. For example, TBMS can react with chloroacetonitrile to form tert-butyl(dimethylamino)methylchlorosilane, which can be further transformed into the herbicide metamitron.
3. Polymers: TBMS is used as a crosslinking agent and a silane coupling agent in the production of rubber, plastics, and composites. For example, TBMS can react with polyolefins to form functionalized polymers that have improved adhesion, surface properties, and mechanical properties.
4. Specialty chemicals: TBMS is used as a versatile reagent for various chemical transformations, such as protection, deprotection, and substitution reactions. For example, TBMS can be used as a protecting group for alcohols and amines, which can be selectively removed under mild conditions to reveal the desired functional groups.
Manufacturing of T-Butyldimethylchlorosilane by INNO Specialty Chemicals
INNO Specialty Chemicals is a leading manufacturer and supplier of TBMS in China, with a production capacity of 300 tons per year. The company has a state-of-the-art production facility that uses advanced technology and strict quality control to ensure the purity, consistency, and safety of its TBMS products.
The manufacturing process of TBMS by INNO Specialty Chemicals involves the reaction of tert-butyl alcohol with dimethylchlorosilane in the presence of a Lewis acid catalyst, such as aluminum chloride or zinc chloride. The reaction is carried out under controlled conditions of temperature, pressure, and reaction time to optimize the yield and purity of TBMS. The resulting TBMS product is then purified by distillation and stored in sealed containers for transportation and storage.
Conclusion
T-Butyldimethylchlorosilane is a versatile reagent that has various applications in the chemical industry, such as pharmaceuticals, agrochemicals, polymers, and specialty chemicals. INNO Specialty Chemicals is a reliable and reputable manufacturer and supplier of TBMS in China, with a strong commitment to quality, innovation, and customer satisfaction. As the demand for TBMS continues to grow in various markets, INNO Specialty Chemicals is well-positioned to provide high-quality and cost-effective TBMS products to its customers worldwide.
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