.
1-(Trimethylsilyl)imidazole: An Overview
INNO Specialty Chemicals is a renowned manufacturer and supplier of various chemical products from China. One of their flagship products is 1-(Trimethylsilyl)imidazole, commonly known as TMSI. This chemical compound has gained immense popularity in the chemical industry due to its numerous applications.
TMSI is a reagent used in organic synthesis as well as in pharmaceuticals. It is a white or colorless crystalline powder with a molecular weight of 162.30 and a boiling point of 83-84°C. The chemical formula for TMSI is C6H12N2Si, and the CAS number is 18106-02-4.
Applications of 1-(Trimethylsilyl)imidazole
1. Dehydrating Agent
TMSI is a powerful dehydrating agent that selectively removes water from alcohols, ketones, and other polar compounds. It is used in the preparation of anhydrides, esters, and lactones. The reaction takes place in the presence of an acid catalyst, and the by-product is trimethylsilanol.
2. Protecting Group
TMSI is also used as a protecting group for amines and alcohols. It selectively protects the primary amine or alcohol groups, leaving the secondary and tertiary groups unaffected. The protection is reversible, and the group can be removed under mild conditions.
3. Nucleophile
TMSI is a strong nucleophile that attacks electrophilic species such as carbonyl compounds, epoxides, and iminium salts. It is used in the synthesis of various compounds such as α,β-unsaturated ketones, β-lactams, and imidazolium salts.
4. Catalyst
TMSI is an efficient catalyst for various reactions such as Friedel-Crafts acylation, alkylation, and cross-coupling reactions. It can also catalyze the cyclization of alkenes to form cycloalkenes and the oxidation of alcohols to aldehydes or ketones.
5. Pharmaceutical Intermediate
TMSI is an essential intermediate in the synthesis of various pharmaceuticals such as antifungal agents, antiviral agents, and anticancer drugs. It is used in the preparation of intermediates for the synthesis of drugs such as fluconazole, voriconazole, and posaconazole.
Conclusion
1-(Trimethylsilyl)imidazole is a versatile chemical compound with numerous applications in organic synthesis and pharmaceuticals. INNO Specialty Chemicals, a leading manufacturer and supplier of TMSI from China, provides high-quality products to meet the demands of the chemical industry. Its unique properties make it a valuable reagent for various chemical reactions, and its applications continue to expand in the future.
Location：