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1-(3,4-dichlorophenyl)-3-phenylurea: An overview of its uses, properties, and safety

INNO SPECIALTY CHEMICALS is a leading manufacturer and supplier of 1-(3,4-dichlorophenyl)-3-phenylurea, also known as triclocarban or TCC. This chemical compound is widely used in the cosmetic and personal care industries as an antimicrobial agent and preservative. It is also used in some consumer products, such as soaps, detergents, and plastics.

In this article, we will provide an overview of the properties, uses, and safety of 1-(3,4-dichlorophenyl)-3-phenylurea. We will also discuss some of the concerns and controversies surrounding its use and potential risks.

Properties and uses

1-(3,4-dichlorophenyl)-3-phenylurea is a white crystalline powder that is soluble in water and organic solvents. It has a molecular weight of 315.17 g/mol and a melting point of 250-252°C. It is typically synthesized by reacting 3,4-dichloroaniline and phenyl isocyanate in the presence of a catalyst.

As mentioned, 1-(3,4-dichlorophenyl)-3-phenylurea is primarily used as an antimicrobial agent and preservative in cosmetic and personal care products. It is effective against a wide range of bacteria and fungi, including Staphylococcus aureus, Escherichia coli, and Candida albicans. It is commonly used in soaps, deodorants, toothpastes, and other personal care products to prevent the growth of odor-causing bacteria.

In addition to its antimicrobial properties, 1-(3,4-dichlorophenyl)-3-phenylurea is also used as a plasticizer in some polymer applications. It can improve the flexibility, durability, and resistance to abrasion of certain plastics, such as polyvinyl chloride (PVC).

Safety and concerns

While 1-(3,4-dichlorophenyl)-3-phenylurea is generally regarded as safe for use in cosmetics and personal care products, there are some concerns about its potential risks to human health and the environment.

One major concern is its potential to contribute to the development of antibiotic resistance. Some studies have suggested that exposure to triclocarban and other antimicrobial agents can promote the growth of antibiotic-resistant bacteria, which could pose a significant threat to public health.

Another concern is its potential to disrupt hormone function. Triclocarban has been shown to have weak estrogenic activity, meaning it can mimic the effects of the hormone estrogen in the body. This has raised concerns about its potential to interfere with the normal functioning of the endocrine system, which could have a range of negative health effects.

There are also concerns about the environmental impact of 1-(3,4-dichlorophenyl)-3-phenylurea. Triclocarban is known to be persistent in the environment and can accumulate in waterways and soil. It has been detected in wastewater, surface water, and sediment, and has been shown to have toxic effects on aquatic organisms.

Conclusion

In conclusion, 1-(3,4-dichlorophenyl)-3-phenylurea is a versatile and widely used chemical compound with a range of applications in the cosmetic and personal care industries. While it is generally regarded as safe for use in these products, there are some concerns about its potential risks to human health and the environment, particularly its potential to contribute to antibiotic resistance and disrupt hormone function. It is important for manufacturers and consumers to be aware of these concerns and take steps to minimize their exposure to triclocarban and other potentially harmful chemicals.

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