1,3-Bis(trimethylsilyl)urea: Properties, Applications, and Manufacturer

1,3-Bis(trimethylsilyl)urea, also known as N,N-Bis(trimethylsilyl)urea or bistrimethylsilylurea, is a versatile organic compound that finds applications in various fields, such as organic synthesis, catalysis, and pharmaceuticals. It has the chemical formula (CH3)6Si2N2O and the molecular weight of 226.48 g/mol. The product is a white or light yellow powder or crystals that are soluble in common organic solvents, such as dichloromethane, diethyl ether, and tetrahydrofuran.

INNO Specialty Chemicals is a leading manufacturer and supplier of 1,3-Bis(trimethylsilyl)urea in China, offering high-quality products at competitive prices. The company has a state-of-the-art production facility that uses advanced technologies and strict quality control measures to ensure the purity, consistency, and safety of its products. INNO Specialty Chemicals also provides customized solutions and technical support to meet the specific needs of its customers.

Properties of 1,3-Bis(trimethylsilyl)urea

1,3-Bis(trimethylsilyl)urea has several properties that make it a useful compound in various applications. For instance, it is a stable, non-toxic, and non-flammable substance that has a low reactivity and high thermal stability. It can withstand high temperatures and pressures without decomposing or reacting with other substances, making it suitable for use in harsh chemical environments.

The product also has a high solubility in organic solvents, which allows it to dissolve and react with a wide range of organic compounds. It has a basic nature due to the presence of the urea group, which can participate in acid-base reactions and form salts with acids. The bis(trimethylsilyl) groups are lipophilic and hydrophobic, which can enhance the solubility and stability of the product in organic media.

Applications of 1,3-Bis(trimethylsilyl)urea

1,3-Bis(trimethylsilyl)urea has various applications in organic synthesis, catalysis, and pharmaceuticals. Some of the common uses of the product are as follows:

1. Protection of carbonyl groups: 1,3-Bis(trimethylsilyl)urea is a useful reagent for the protection of carbonyl groups in organic synthesis. It can selectively react with ketones, aldehydes, and esters to form stable trimethylsilyl enol ethers, which can be deprotected later with mild acid or fluoride ion. The protection of carbonyl groups can prevent unwanted reactions or side products and allow for the efficient synthesis of complex molecules.

2. Dehydration of amides: 1,3-Bis(trimethylsilyl)urea can also act as a dehydrating agent for amides, leading to the formation of nitriles. This reaction can be useful for the preparation of nitrile-containing compounds, which are important intermediates in many organic syntheses.

3. Catalysis of organic reactions: 1,3-Bis(trimethylsilyl)urea can act as a Lewis acid catalyst in various organic reactions, such as Diels-Alder reactions, aldol condensations, and Michael additions. The bis(trimethylsilyl) groups can enhance the electrophilicity of the urea group and promote the formation of reactive intermediates. The product can also stabilize the transition states and lower the activation energies of the reactions, leading to higher yields and selectivities.

4. Pharmaceutical applications: 1,3-Bis(trimethylsilyl)urea has potential applications in the development of new drugs and therapies. It can act as a prodrug or a carrier molecule for various drugs, such as antitumor agents, antibiotics, and anti-inflammatory agents. The lipophilic nature of the bis(trimethylsilyl) groups can enhance the bioavailability and the target specificity of the drugs, leading to improved efficacy and reduced side effects.

Conclusion

1,3-Bis(trimethylsilyl)urea is a versatile organic compound that has various properties and applications in organic synthesis, catalysis, and pharmaceuticals. INNO Specialty Chemicals is a reliable and experienced manufacturer and supplier of the product in China, offering high-quality products and customized solutions to meet the diverse needs of its customers. With its unique properties and potential applications, 1,3-Bis(trimethylsilyl)urea is a promising compound that can contribute to the advancement of various fields of science and technology.

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