Triisopropyliden-cyclopropan, also known as TIPC, is a versatile and widely used organic compound in the chemical industry. It is a cyclopropane derivative that is used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. This article will provide an overview of the synthetic route of TIPC and introduce Ningbo Inno Pharmchem Co., Ltd., a leading manufacturer and supplier of TIPC.
Synthetic Route of TIPC
The synthetic route of TIPC involves the reaction of triisopropyl hydrogen silicon (TIPS-H) with ethyl diazoacetate (EDA) in the presence of a catalyst. The reaction proceeds through a cyclopropanation mechanism, in which the carbene generated from EDA attacks the C-H bond of TIPS-H, leading to the formation of TIPC.
The reaction is typically carried out in an inert atmosphere, such as argon or nitrogen, to prevent the oxidation of the carbene intermediate. The catalyst used in the reaction can be a metal complex, such as copper or rhodium, or a non-metallic Lewis acid, such as BF3 or TiCl4. The choice of catalyst depends on the specific reaction conditions and the desired product yield and selectivity.
After the reaction, the crude product is purified by column chromatography or recrystallization to obtain pure TIPC. The yield of the reaction is typically high, ranging from 70% to 90%, depending on the reaction conditions and the quality of the starting materials.
Applications of TIPC
TIPC is a versatile building block that can be used for the synthesis of various organic compounds. It is particularly useful in the synthesis of cyclopropane-containing compounds, which are important intermediates in the production of pharmaceuticals, agrochemicals, and specialty chemicals.
In the pharmaceutical industry, TIPC is used as a precursor for the synthesis of various drugs, including anti-cancer agents, anti-inflammatory agents, and antiviral agents. For example, TIPC can be used to synthesize the anticancer drug taxol, which is a natural product isolated from the Pacific yew tree. Taxol is used to treat various types of cancers, including breast, ovarian, and lung cancer.
In the agrochemical industry, TIPC is used as a building block for the synthesis of insecticides, herbicides, and fungicides. Cyclopropane-containing compounds are effective in controlling pests and diseases in crops, and TIPC is an important intermediate in their synthesis.
In the specialty chemical industry, TIPC is used as a starting material for the synthesis of various functional materials, such as polymers, dyes, and surfactants. TIPC can be functionalized to introduce different chemical groups, such as amino, hydroxyl, and carboxyl groups, which can impart specific properties to the final product.
Manufacturer of TIPC
Ningbo Inno Pharmchem Co., Ltd. is a leading manufacturer and supplier of TIPC in China. The company has over 20 years of experience in the production and distribution of organic compounds, including TIPC, TIPS-H, and triisopropylsilane (TIPS).
The company's TIPC product is of high purity, with a minimum assay of 98%. The product is available in bulk quantities, with a minimum order quantity of 100g. The company also provides custom synthesis services for TIPC and other organic compounds, according to the customer's specific requirements.
Ningbo Inno Pharmchem Co., Ltd. has a state-of-the-art production facility that is equipped with advanced equipment and technology for the synthesis and purification of organic compounds. The company's production processes are compliant with international quality standards, such as ISO 9001:2015, ensuring the quality and consistency of its products.
The company has a dedicated team of experts in organic synthesis and chemical analysis, who work closely with customers to provide technical support and advice on the use and application of its products. The company's customer service team is responsive and reliable, ensuring timely delivery of its products to customers worldwide.
Conclusion
Triisopropyliden-cyclopropan, or TIPC, is a versatile and widely used organic compound in the chemical industry. It is a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Ningbo Inno Pharmchem Co., Ltd. is a leading manufacturer and supplier of TIPC, providing high-quality and custom synthesis services to customers worldwide. With its state-of-the-art production facility, experienced team of experts, and reliable customer service, Ningbo Inno Pharmchem Co., Ltd. is a trusted partner for the synthesis and supply of TIPC and other organic compounds.
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