N,O-Bistrimethylsilylacetamide: Properties, Applications, and Manufacturer
N,O-Bistrimethylsilylacetamide: Properties, Applications, and Manufacturer
N,O-Bistrimethylsilylacetamide (BSA) is an organic compound that belongs to the family of silylamides. It is a colorless to slightly yellow liquid with a molecular formula of C8H21NOSi2 and a molecular weight of 207.43 g/mol. BSA is synthesized by reacting trimethylsilyl chloride with acetamide in the presence of a base such as triethylamine. The resulting product is purified by distillation or chromatography.
BSA is widely used as a reagent and an intermediate in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and functional materials. It is valued for its ability to protect sensitive functional groups and enhance the regioselectivity and stereoselectivity of various reactions. BSA can also act as a Lewis base, forming stable complexes with Lewis acids such as boron trifluoride and titanium tetrachloride. Moreover, BSA can be used as a solvent for inorganic salts and some organic compounds.
One of the main advantages of BSA is its high thermal stability and low volatility, which make it suitable for high-temperature reactions and distillations. BSA has a boiling point of 170-173°C at atmospheric pressure and a flash point of 62°C. It is soluble in most organic solvents such as ether, chloroform, and toluene, but insoluble in water.
In the pharmaceutical industry, BSA is commonly used as a protecting group for amines and carboxylic acids, which are key building blocks for many drugs. By attaching a trimethylsilyl group to the amine or carboxylic acid, the compound becomes more stable and less reactive towards unwanted side reactions. The silyl group can be easily removed later in the synthesis by mild acidic or basic conditions.
In the agrochemical industry, BSA is used as a precursor for various herbicides, insecticides, and fungicides. For example, BSA can be used to synthesize the herbicide pendimethalin, which is used to control grass weeds in crops such as soybean and corn. BSA can also be used to make the fungicide azoxystrobin, which is used to protect fruits and vegetables from fungal diseases.
In the field of materials science, BSA is used as a cross-linking agent for polymers and as a surface modifier for inorganic materials such as silica and alumina. BSA can form strong bonds with functional groups on the polymer or the surface, leading to improved mechanical and chemical properties. For example, BSA can be used to modify the surface of silica particles to enhance their dispersibility and stability in various solvents.
As a manufacturer and supplier of BSA, INNO SPECIALTY CHEMICALS provides high-quality products and customized solutions to customers worldwide. INNO has a dedicated team of experts who can assist customers in selecting the most suitable BSA grade for their specific application and provide technical support throughout the entire process. INNO's BSA products are manufactured in compliance with international standards and undergo rigorous quality control to ensure consistent performance and purity.
In conclusion, N,O-Bistrimethylsilylacetamide is a versatile and valuable compound that has a wide range of applications in various industries. Its unique properties make it an ideal reagent and intermediate for organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and functional materials. INNO SPECIALTY CHEMICALS is a reliable and experienced manufacturer and supplier of BSA, offering high-quality products and customized solutions to meet customers' needs.
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