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Permissions Request permissions Determination of UV-327 and its metabolites in human urine using dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry C. Fischer and T. Göen, Anal. Methods, 2021, 13, 3978 DOI: 10.1039/D1AY00932J To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page. Read more about how to correctly acknowledge RSC content. This is unique source of information on the chemicals manufactured and imported in Europe. It covers their hazardous properties, classification and labelling, and information on how to use them safely. 2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol. Acts as a highly effective light stabilizer for a variety of plastics and other substrates. Due to its red-shifted UV absorption, is particularly suited for use in the stabilization of polymers that are especially sensitive to long-wavelength UV radiation and in certain applications where very low transmission of long-wavelength UV radiation is required (e.g. optical lenses). Read More View less This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). The source of the information is mentioned in the introductory sentence of the hazard statements. When information is available in all sources, the first two are displayed as a priority. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215–540–4, is covered by three harmonisations: 005–011–00–4; 005–011–01–1 and 005–011–02–9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically generated for the InfoCard. Determination of UV-327 and its metabolites in human urine using dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry C. Fischer and T. Göen, Anal. Methods, 2021, 13, 3978 DOI: 10.1039/D1AY00932J To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given. If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page. Read more about how to correctly acknowledge RSC content. The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. in case of consumer and professional uses). Other relevant information includes the following: The benzotriazole UV stabilizer (BUVS) 2-(5-chloro-benzotriazol-2-yl)-4,6-di-(tert-butyl)phenol (UV-327) is added to plastic materials for UV protection. The compound is known to be ubiquitously distributed in the environment. We developed the first analytical method for the determination of UV-327 and seven metabolites, which were identified in vitro, in urine to be able to investigate the in vivo metabolism of UV-327 and to assess potential human exposure to the compound. Enzymatic hydrolysis of phase II conjugates is followed by sample purification with dispersive liquid-liquid microextraction (DLLME). The analytes are extracted from the urine samples after acidification with hydrochloric acid solution and addition of sodium chloride solution. Isopropyl alcohol and chloroform are used as disperser solvent and extraction solvent, respectively. After derivatization, the trimethylsilylated analytes are chromatographically separated and detected by gas chromatography coupled with tandem mass spectrometry (GC-MS/MS). To achieve maximum extraction of the analytes from the sample solution, the DLLME procedure was optimized with respect to the type and volume of disperser and extraction solvent, the pH value of the sample solution, the addition of salt, and the duration of vortex-mixing. Subsequent method validation demonstrated high sensitivity and reliability, with limits of detection (LODs) between 0.05 and 0.1 μg l−1 and mean relative recovery rates ranging from 88 to 112%. Precision and repeatability were proven by relative standard deviations ranging from 1 to 13% and from 5 to 14%, respectively.

INNO SPECIALTY CHEMICALS is also Methyldiphenylsilanol manufacturer and Laureth-2 supplier.

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