Introduction

1,1,1-Trifluoro-2-iodoethane, with the chemical formula C2H2F3I, is a halogenated organic compound widely recognized in the field of chemistry for its unique properties. Often referred to by synonyms such as trifluoro iodoethane, Trifluoroethyl iodide, or 2,2,2-Trifluoroethyl Iodide, this compound stands out due to its combination of fluorine and iodine atoms. Its CAS number is 353-83-3, and it boasts a molecular weight of 209.94 g/mol. The trifluoromethyl group (-CF3) paired with an iodine atom makes it an essential intermediate in various chemical processes, notably in organic synthesis and pharmaceutical development.

Chemical Identity

Officially named 1,1,1-trifluoro-2-iodoethane, this compound is known by an array of alternative names that highlight its prominence in chemical literature. These include trifluoro iodoethane, Trifluoroethyl iodide, 2,2,2-Trifluoroiodoethane, 2-Iodo-1,1,1-trifluoroethane, 2,2,2-trifluoro-1-iodoethane, 1,1,1-Trifluoroiodoethane, Ethane, 1,1,1-trifluoro-2-iodo-, 2,2,2-Trifluoroethyl Iodide, 1-iodo-2,2,2-trifluoroethane, and 1,1,1-trifluoro-2-iodo-ethane. This diversity in nomenclature underscores its broad application and recognition across scientific communities.

Physical Properties

At room temperature, 1,1,1-trifluoro-2-iodoethane exists as a liquid with a density of 2.13 g/mL at 25°C, a characteristic high value attributable to the heavy iodine atom. Its boiling point is 54.8°C, suggesting moderate volatility that facilitates purification or separation through distillation. The flash point ranges between 53-55°C, indicating the temperature at which it can ignite in the presence of an open flame, a critical factor for safe handling. With a refractive index of n20/D 1.401, it bends light in a manner useful for identification and analysis. Visually, it appears as a clear colorless to pink liquid, with its hue potentially shifting due to light exposure or impurities over time.

Chemical Properties

Supplied with a purity of at least 98.0%, 1,1,1-trifluoro-2-iodoethane meets high standards for use in sensitive chemical reactions. Its moisture content is limited to 0.25%, and impurities are capped at 0.3%, ensuring minimal interference in synthetic processes. The trifluoromethyl group imparts electron-withdrawing effects, enhancing its reactivity in reactions like nucleophilic substitutions. The iodine atom, known as an excellent leaving group, further boosts its utility in organic transformations. This compound is particularly valued for introducing trifluoroethyl groups into molecular structures, a feature leveraged in advanced chemical synthesis.

Synthesis

The production of 1,1,1-trifluoro-2-iodoethane can be achieved through multiple synthetic pathways. A prevalent method involves the halogenation of 1,1,1-trifluoroethane with iodine, often aided by a catalyst to enhance the formation of the C-I bond. Alternative approaches may utilize trifluoromethylating reagents or iodination of fluorinated precursors. These methods are refined by manufacturers to optimize yield and purity, catering to industrial demands where scalability and efficiency are paramount.

Applications

1,1,1-Trifluoro-2-iodoethane serves as a cornerstone in organic synthesis and pharmaceutical production. It is employed as an intermediate to incorporate the trifluoroethyl group into compounds, modifying their physical and biological profiles. In pharmaceuticals, fluorinated molecules are celebrated for their enhanced stability, lipophilicity, and bioavailability, making this compound crucial. Specifically, the applications of CAS 353-83-3 in pharmaceuticals include crafting fluorinated drug analogs that improve therapeutic effectiveness. Beyond medicine, it contributes to agrochemicals, dyes, and materials science, where fluorination enhances properties like durability and resistance. Its role in palladium-catalyzed cross-coupling reactions with boronic acid esters further exemplifies its versatility, enabling the creation of complex fluorinated aromatics.

Storage and Handling

To preserve its integrity, 1,1,1-trifluoro-2-iodoethane must be stored in a tightly sealed container within a cool, dry, and well-ventilated space, isolated from reactive substances like strong oxidizers. Its flammability, indicated by a flash point of 53-55°C, necessitates precautions against ignition sources. Handling requires protective gear such as gloves and goggles to prevent contact with skin or eyes. Adherence to safety data sheets and local regulations ensures its safe use and disposal, protecting both personnel and the environment.

Market and Suppliers

Globally available, 1,1,1-trifluoro-2-iodoethane is supplied by numerous manufacturers, with China emerging as a key production center. Selecting a reliable 1,1,1-trifluoro-2-iodoethane manufacturer in China or a trusted trifluoro iodoethane supplier in China involves evaluating their quality assurance and production standards. High purity and consistent supply are vital, making it essential to partner with reputable providers who offer detailed specifications and safety data, ensuring the compound meets industrial and research needs effectively.

Conclusion

1,1,1-Trifluoro-2-iodoethane stands as a pivotal compound in chemistry, bridging organic synthesis and pharmaceutical innovation with its distinctive fluorine-iodine composition. Its applications enhance molecular properties across industries, while proper storage and sourcing from quality suppliers ensure its efficacy. Beyond offering this compound, our company excels in the research, development, and production of fine chemicals and pharmaceutical intermediates. We specialize in continuous flow process development and manufacturing, adept at high-temperature, high-pressure, nitration, oxidation, and continuous distillation reactions. Our services cover products from 100 kgs to 100 MT annually, with up to 5 synthetic steps. For further needs, please feel free to contact us.

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