Introduction to Methyl 2-Iodobenzoate

Methyl 2-Iodobenzoate, identified by its CAS number 610-97-9, is a versatile organic compound widely recognized in the chemical and pharmaceutical industries. Known by various synonyms such as Methyl o-iodobenzoate, 2-Iodo-Benzoic Acid Methyl Ester, and Benzoic acid, 2-iodo-, methyl ester, this compound boasts a molecular formula of C8H7IO2 and a molecular weight of 262.04400. Its significance lies in its unique chemical structure, which makes it a valuable intermediate in the synthesis of numerous high-value products.

This light yellow liquid stands out due to its specific physical and chemical properties, which enable its use in specialized applications. With a growing demand for pharmaceutical intermediates globally, Methyl 2-Iodobenzoate has become a focal point for researchers and manufacturers alike, particularly those seeking reliable suppliers in China.

Chemical and Physical Properties of Methyl 2-Iodobenzoate

The compound exhibits distinct characteristics that define its utility. It has a density of 1.784 g/mL at 25°C, a boiling point ranging from 149-150°C at 10 mm Hg, and a melting point of 64°C. Its flash point exceeds 230°F, indicating relative stability under high-temperature conditions, while its refractive index is measured at n20/D 1.604. These properties ensure that Methyl 2-Iodobenzoate remains effective in controlled industrial processes.

In terms of purity, the product is typically offered at ≥98%, with moisture content kept below 0.1% and impurities limited to ≤0.5%. Such specifications are critical for its role in precision-driven applications, ensuring consistency and quality in downstream processes. Proper storage in a cool, dry, and well-closed container, away from moisture and strong light or heat, further preserves its integrity.

Applications in Pharmaceutical Intermediates

One of the standout uses of Methyl 2-Iodobenzoate is as an intermediate in the synthesis of Montelukast (CAS: 158966-92-8), a well-known medication for asthma and allergy management. This application underscores its importance in the pharmaceutical sector, where precision and purity are non-negotiable. The compound’s iodine atom and ester functional group facilitate key chemical reactions, such as cobalt-catalyzed cyclization with aldehydes to produce phthalide derivatives, which are building blocks for various bioactive molecules.

Beyond Montelukast, Methyl 2-Iodobenzoate serves as a precursor in the preparation of other complex compounds. Its reactivity with trivalent iodine compounds enables mild oxidations, oxidative couplings, and special iodinations, making it a preferred choice for synthesizing advanced pharmaceutical intermediates. This versatility has fueled its demand among manufacturers in China and beyond, positioning it as a critical component in drug development pipelines.

Manufacturing and Supply Chain Insights

The production of Methyl 2-Iodobenzoate involves esterification of 2-iodobenzoic acid with methanol, a process that requires careful control to achieve high yields and purity. As a leading Methyl 2-Iodobenzoate manufacturer in China, NINGBO INNO PHARMCHEM CO.,LTD. leverages advanced techniques to meet global standards. The product is typically packaged in 25kg cardboard drums or customized according to client needs, ensuring safe transportation and storage.

China has emerged as a hub for chemical manufacturing due to its robust infrastructure and cost-effective production capabilities. Companies seeking a Methyl 2-Iodobenzoate supplier in China benefit from access to high-quality products at competitive prices, supported by a reliable supply chain. The ability to scale production from kilograms to metric tons further enhances its appeal for industrial buyers.

Role in Research and Development

Beyond its industrial applications, Methyl 2-Iodobenzoate plays a pivotal role in research settings. Its use in microbial dihydroxylation processes, for instance, yields nonracemic iodocyclohexene carboxylate intermediates, which are precursors to complex molecules like kibdelone C, a potential therapeutic agent. This highlights its value in cutting-edge chemical synthesis, where innovation drives the discovery of new compounds.

Researchers also explore its potential in developing environmentally friendly oxidants, replacing traditional metal-based reagents with iodosobenzoates derived from Methyl 2-Iodobenzoate. This shift aligns with global trends toward sustainable chemistry, further elevating the compound’s relevance. For those in need of a Methyl 2-Iodobenzoate CAS 610-97-9 supplier in China, partnering with a manufacturer that prioritizes R&D ensures access to tailored solutions and consistent quality.

Market Trends and Future Prospects

The global market for pharmaceutical intermediates like Methyl 2-Iodobenzoate is expanding, driven by rising healthcare demands and advancements in drug discovery. China’s dominance in chemical production positions it as a key player, with manufacturers continuously optimizing processes to meet stringent international regulations. The compound’s role in synthesizing high-demand drugs like Montelukast ensures its steady growth trajectory.

Looking ahead, innovations in continuous flow chemistry and green manufacturing techniques could further enhance its production efficiency. As industries prioritize sustainability, the adaptability of Methyl 2-Iodobenzoate in eco-friendly processes will likely bolster its market presence. Businesses seeking long-term partnerships with a Methyl 2-Iodobenzoate manufacturer in China can expect ongoing improvements in product quality and supply reliability.

Our Other Services

At NINGBO INNO PHARMCHEM CO.,LTD., our expertise extends beyond Methyl 2-Iodobenzoate. Our primary business scope encompasses the research, development, and production of fine chemicals and pharmaceutical intermediates. We specialize in continuous flow process development and equipment manufacturing, supported by our in-house pilot workshop and external large-scale production platforms. Our proficiency covers reaction types such as high-temperature, high-pressure, nitration, oxidation, and continuous distillation.

Our R&D and manufacturing services include a wide range of products like bromides, boric acids, thiophenes, indoles, imidazoles, thiazoles, piperazines, pyrazines, and more, with production capacities ranging from tons to hundreds of tons. We focus on products with annual volumes between 100 kgs and 100 MT, typically involving up to five synthetic steps. If you have additional needs, please feel free to contact us for customized solutions tailored to your requirements.

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