Introduction to 1-Bromo-3-Chloropropane

1-Bromo-3-Chloropropane, identified by its CAS number 109-70-6, is a halogenated organic compound widely recognized in the chemical industry. Known by various synonyms such as Propane, 1-bromo-3-chloro-, 3-Bromopropyl Chloride, and 3-Chloropropyl Bromide, this compound plays a crucial role as an intermediate in organic synthesis. Its molecular formula, C3H6BrCl, and molecular weight of 157.43700 underscore its compact yet reactive nature, making it a valuable asset in multiple applications.

This colorless transparent liquid exhibits unique physical and chemical properties that enhance its utility. With a density of 1.592 g/cm³, a melting point of -59ºC, and a boiling point ranging from 144-145ºC, it remains stable under specific conditions while being highly reactive when required. These characteristics position 1-Bromo-3-Chloropropane as a preferred choice for researchers and manufacturers alike.

Chemical and Physical Properties

The compound’s physical attributes include a flash point of 81ºC and an index of refraction of 1.486, indicating its behavior under heat and light. It is insoluble in water, a property attributed to the presence of bromine and chlorine atoms, which increase its density and reduce its polarity. Specifications for industrial-grade 1-Bromo-3-Chloropropane demand an assay of at least 99.5%, with moisture content not exceeding 0.05% and a color rating of ≤20 APHA. Such stringent standards ensure its purity and effectiveness in sensitive applications.

Chemically, 1-Bromo-3-Chloropropane is electrophilic due to the high electronegativity of its halogen substituents. This property facilitates nucleophilic substitution reactions, making it an essential building block in synthesizing complex molecules. However, it requires careful handling, as it is flammable and can irritate the skin, eyes, and respiratory system upon exposure.

Applications in Organic Synthesis

One of the primary uses of 1-Bromo-3-Chloropropane is as an organic synthesis intermediate. Its structure, featuring a three-carbon chain with bromine on one end and chlorine on the other, serves as a versatile C3 linker or spacer in molecular construction. This functionality is particularly valuable in the pharmaceutical industry, where it aids in producing active pharmaceutical ingredients (APIs) for drugs addressing cardiovascular diseases, pain relief, and other conditions.

Beyond pharmaceuticals, this compound finds application in research settings. It acts as a phase-separation agent in RNA isolation, offering a safer alternative to chloroform. Its ability to maintain RNA integrity during extraction from biological samples highlights its importance in molecular biology. Additionally, its role in synthesizing polymer nanoparticles for drug delivery systems underscores its adaptability across scientific domains.

Manufacturing and Supply in China

China stands out as a global hub for the production of 1-Bromo-3-Chloropropane, with numerous facilities dedicated to its manufacture. The compound is typically packaged in 200 kg drums, though customization is available to meet specific customer needs. Manufacturers in China prioritize quality, adhering to standards that guarantee an assay of ≥99.0%, as evidenced by test results showing 99.59% purity and water content as low as 0.06%. This reliability makes 1-Bromo-3-Chloropropane manufacturer in China a sought-after keyword in the chemical trade.

Suppliers in China also emphasize storage conditions, recommending cool, ventilated environments to preserve the compound’s stability. The production process often involves the free-radical addition of hydrogen bromide to allyl chloride, a method that ensures efficiency and consistency. As a result, 1-Bromo-3-Chloropropane supplier in China has become synonymous with high-quality intermediates for global markets.

Quality Control and Specifications

Quality assurance is paramount in the production of 1-Bromo-3-Chloropropane. Analytical standards specify a colorless to light yellow clear liquid, with test results often confirming a colorless clear liquid that meets factory benchmarks. Loss on drying is kept below 0.1%, ensuring minimal impurities. These parameters are critical for industries relying on 1-Bromo-3-Chloropropane CAS 109-70-6 supplier in China to deliver consistent performance in their processes.

The compound’s stability at room temperature, coupled with its susceptibility to elimination reactions under high heat or strong bases, necessitates precise handling protocols. Manufacturers provide detailed safety data, advising protective gear and ventilation to mitigate its harmful effects if inhaled or contacted.

Global Relevance and Future Prospects

The global demand for 1-Bromo-3-Chloropropane continues to grow, driven by its applications in pharmaceuticals, biotechnology, and materials science. Its role as a replacement for more hazardous chemicals like chloroform positions it as a forward-thinking solution in laboratory practices. As industries seek sustainable and efficient intermediates, this compound’s versatility ensures its relevance in future innovations.

China’s robust manufacturing infrastructure supports this demand, offering competitive pricing and scalable production. Companies searching for 1-Bromo-3-Chloropropane manufacturer in China benefit from a supply chain that balances quality with accessibility, fostering international collaboration in chemical advancements.

Our Additional Services

At NINGBO INNO PHARMCHEM CO.,LTD., we extend beyond supplying 1-Bromo-3-Chloropropane to offer comprehensive services in fine chemicals and pharmaceutical intermediates. Our expertise spans research and development, production, and continuous flow process development. We specialize in manufacturing continuous flow equipment and operate our own pilot workshops alongside large-scale production platforms through external partnerships. Our proficient reaction types include high-temperature, high-pressure, nitration, oxidation, and continuous distillation processes.

Our R&D and manufacturing services cover a wide range of compounds, including bromide, boric acid, thiophene, indole, imidazole, thiazole, piperazine, and pyrazine derivatives. We cater to production volumes from 100 kgs to 100 metric tons annually, focusing on processes with up to five synthetic steps. If you have additional needs in fine chemicals or intermediates, please feel free to contact us for tailored solutions.

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