Product Introduction: 4-Chloro-3-nitroanisole (CAS No.: 10298-80-3)

Overview

4-Chloro-3-nitroanisole, commonly known by its synonyms such as 4-Chloro-3-nitrophenyl methyl ether, is a vital chemical compound utilized primarily in pharmaceutical applications. Notably, it is an important intermediate in the synthesis of Iguratimod, a therapeutic agent used to manage autoimmune diseases.

Chemical Properties

- Molecular Formula: C8H8ClN2O3
- Molecular Weight: 203.61 g/mol
- Appearance: This compound typically appears as a yellow to brown solid.
- Solubility: It is moderately soluble in organic solvents like acetone and ethanol but shows limited solubility in water.

4-Chloro-3-nitroanisole exhibits various functional groups that contribute to its reactivity and utility in chemical synthesis, particularly in electrophilic aromatic substitution reactions.

Quality Standards

The quality of 4-Chloro-3-nitroanisole is often assessed based on stringent specifications to ensure its suitability for pharmaceutical applications. Typical quality standards include:

- Purity: ≥ 98%
- Moisture Content: ≤ 0.5%
- Melting Point: 50-54°C
- Heavy Metals: < 10 ppm

These standards help confirm the compound''s efficacy and safety when used in drug formulation.

Applications in Pharmaceutical Industry

As an essential intermediate, 4-Chloro-3-nitroanisole plays a crucial role in the synthesis of Iguratimod. This drug is primarily used for treating chronic inflammatory conditions, such as rheumatoid arthritis. The compound’s ability to contribute to the formation of complex structures makes it invaluable in developing potent therapeutic agents.

Furthermore, the versatility of 4-Chloro-3-nitroanisole allows it to find applications in various synthetic pathways beyond Iguratimod, including the development of agrochemicals and other pharmaceuticals.

Conclusion

4-Chloro-3-nitroanisole (CAS No.: 10298-80-3) is a significant chemical entity with diverse applications, especially within the realms of pharmaceutical chemistry and synthetic processes. Its role in the synthesis of Iguratimod underscores its importance in addressing medical needs related to autoimmune diseases. The compound''s quality and chemical properties make it an essential component in drug development and other industrial applications.

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